研究员

陈卓

  • 职称:研究员
  • 学科:
  • 电子邮件:zchen@fjirsm.ac.cn
  • 研究方向:

    肿瘤生物学

简介

陈卓,研究员,博士生导师。中国科学院海西院“百人计划”入选者、福建省引进高层次创新人才、福建省省级高层次人才(B类)。主要从事光化学、光生物学及光动力学疗法的基础与转化研究,深入探索其作用机制及成像介导疗法的优化,在肿瘤标志物监测与癌症治疗等方面取得重要成果。在国际著名期刊发表100余篇论文,其中4篇为封面/封底/卷首彩页论文,近五年他引超4900次,3篇入选ESI高被引频次(top 1%)论文。合作出版英文专章1篇,获19项国内外发明专利。研究成果多次被国内外权威媒体专栏报道,三次入选年度“中国稀土十大科技新闻”。至今已主持并完成6项国家自然科学基金面上项目,目前在研的国家重点研发计划、物构所“前瞻跨越”揭榜挂帅项目等,主要涉及新型纳米荧光生物标记材料对重大疾病(如肿瘤)标志物的检测及靶向生物成像、光动力抗肿瘤及抗病原菌等领域。
目前担任《中国医药导报》、《海峡药学》等期刊编委、中国光学学会生物医学光子学专委会委员、福建省生物工程学会常务理事、福建省药理学会肿瘤药理专业委员会常委、以及中国化学会、中国药学会、中国药理学会、中国光学学会、RSC、Elsevier、Wiley-VCH、Springer等多种SCI国际刊物审稿专家。

代表性论著

1. Wei Lian, Qianqi Yang, Yuhan Liu, Datao Tu*, Xiaoying Shang, Bowen Li, Ping Hu, Wei Zheng*, Zhuo Chen*, Xueyuan Chen*, “Near-infrared-LED photostimulated luminescent nanoprobes based on lanthanide-doped SrS nanocrystals”, Chemical Engineering Journal 2024, 494, 152958.

2. Hongyu Wang, Xiaohong Pan*, Wenzhen Liu, Yunmei Huang, Xiaodong Yi, Zhuo Chen*, “Bacterial-mediated FRET between AIE and ACQ photosensitizers for enhanced antimicrobial photodynamic therapy”, Chemical Engineering Journal 2024, 486, 150432.

3. Ruikun Lin, Lei Zhang*, Biwei Ye, Yanan Wang, Yi-Dong Li, Jason Hsu, Wenzhen Liu, Ping Hu, Jincan Chen, Zhe-Sheng Chen, Zhuo Chen*, “A multi-functional nanosystem combining PI3K-110α/β inhibitor overcomes P-glycoprotein mediated MDR and improves anti-cancer efficiency”, Cancer Letters 2023, 563, 216181.

4. Jincan Chen, Yang Zhou, Meiru Song, Yijian Chen, Dong Wang, Yunmei Huang, Ping Hu, Chen He, Tao Dai, Lei Zhang, Mingdong Huang, Zhuo Chen*, Peng Xu*, “A serum-stable supramolecular drug carrier for chemotherapeutics fabricated by a peptide-photosensitizer conjugate”, Journal of Colloid and Interface Science 2023, 646, 959-969.

5. Lei Zhang, Biwei Ye, Zhuo Chen*, Zhesheng Chen*, “Progress in the studies on the molecular mechanisms associated with multidrug resistance in cancers”, Acta Pharmaceutica Sinica B 2023, 13, 982-997.

6. Yaqi Wang, Xiaohong Pan*, Tao Dai, Le Wang, Haixing Shi, Huanhuan Wang, Zhuo Chen*, “An AIE photosensitizer with unquenched fluorescence based on nitrobenzoic acid for tumor-targeting and image-guided photodynamic therapy”, Biomaterials Science 2022, 10, 4866-4875.

7. Yuxiang Zhang, Wenzhen Liu*, Yunmei Huang, Yanhuang Wang, Xueyuan Chen, Zhuo Chen*, “Bacterial biofilm microenvironment responsive copper-doped zinc peroxide nanocomposites for enhancing chemodynamic therapy”, Chemical Engineering Journal 2022, 446, 137214.

8. Xuzhi Wang, Shuzhi Tang, Shengnan Ye, Zhou Cheng, Jianhua Xu, Bo-wen Li*, Zhuo Chen*, “Ultrasensitive quantitation of circulating miR-195-5p with triple strand displacement amplification cascade”, Talanta 2022, 242, 123300.

9. Huanhuan Wang, Xiaohong Pan*, Yaqi Wang, Wenzhen Liu, Tao Dai, Binbin Yuan, Xueyuan Chen, Zhuo Chen*, “A new class of nitrobenzoic acid based AIE photosensitizers for highly efficient photodynamic antibacterial therapy”, Science China-Materials 2021, 64, 2601-2612.

10. Tao Dai, Farong Ye, Ping Hu, Xiaohong Pan, Jincan Chen, Yunmei Huang, Huanhuan Wang, Lei Zhang, Mingdong Huang, Jianyong Liu, Jianqiang Su, Xueyuan Chen, Zhuo Chen*, “A strategy for enhanced tumor targeting of photodynamic therapy based on Escherichia coli-driven drug delivery system”, Science China-Materials 2021, 64, 232-240.

11. Dong Wang, Wenzhen Liu, Le Wang, Yu Wang, Christopher Kai Liao, Jincan Chen, Ping Hu, Wanjin Hong, Mingdong Huang, Zhuo Chen*, Peng Xu*, “Suppression of cancer proliferation and metastasis by a versatile nanomedicine integrating multiple therapeutic mechanisms”, Acta Biomaterialia 2020, 113, 541-553.

12. Lei Zhang, Yidong Li, Qianchao Wang, Zhuo Chen*, Xiaoyun Li, Zhuoxun Wu, Chaohua Hu, Dan Liao, Wei Zhang, Zhesheng Chen*, “The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer”, Molecular Cancer 2020, 19, 10.

13. Wenzhen Liu, Yuxiang Zhang, Wenwu You, Jianqiang Su, Shaohua Yu, Tao Dai, Yunmei Huang, Xueyuan Chen, Xiaorong Song*, Zhuo Chen*, “Near-infrared-excited upconversion photodynamic therapy of extensively drug-resistant Acinetobacter baumannii based on lanthanide nanoparticles”, Nanoscale 2020, 12(26), 13948-13957.

14. Hanhan Guo, Xiaorong Song*, Wen Lei, Cheng He, Wenwu You, Qingzhong Lin, Shanyong Zhou, Xueyuan Chen*, Zhuo Chen*, “Direct detection of circulating tumor cells in whole blood based on time-resolved luminescent lanthanide nanoprobes”, Angewandte Chemie International Edition 2019, 58, 12195-12199.

15. Yuxiang Zhang, Ping Huang, Dong Wang, Jincan Chen, Wenzhen Liu, Ping Hu, Mingdong Huang, Xueyuan Chen*, Zhuo Chen*, “Near-infrared-triggered antibacterial and antifungal photodynamic therapy based on lanthanide-doped upconversion nanoparticles”, Nanoscale 2018, 10, 15485-15495.