有机合成方法学,过渡金属催化,有机功能材料分子的合成与应用
杜宇,研究员。本科以及研究生阶段就读于厦门大学化学化工学院,师从黄培强教授,2011年获得有机化学专业理学博士学位。博士毕业之后在海外工作进行博士后研究。2018年初以引进人才方式进入中国科学院福建物质结构研究所工作,围绕有机合成化学,进行合成方法学、过渡金属催化,以及有机功能材料分子和药物分子的合成与应用研究。近五年来以通讯作者身份发表二区以上文章二十余篇,研究成果发表于Angew. Chem. Int. Ed.,Nat. Commun.,Chin. Chem. Lett.,Org. Lett.,Chem. Commun.等期刊,并主持国家自然科学基金面上项目两项。多年来与材料化学、生物化学、医学等领域研究团队深入合作,开展基于有机合成的应用研究。
1. T. Liu, X. Deng, Y. Gao, H. Li, Y. Du*, W. Su*, Ligand-enabled nondirected and regioselective arylation of internal alkenes with simple arenes, Angew. Chem. Int. Ed., 2025, DOI: 10.1002/anie.202420443.
2. R. Luan, P. Lin, K. Li, Y. Du*, W. Su*, Remote-carbonyl-directed sequential Heck/isomerization/C(sp2)–H arylation of alkenes for modular synthesis of stereodefined tetrasubstituted olefins, Nat. Commun., 2024, 15, 1723.
3. K. Li, R. Luan, Y. Du*, W. Su*, Remote-carbonyl-directed consecutive arylation of terminal alkenes for the synthesis of tetrasubstituted olefins, Synthesis, 2024, 56, 1989–1998.
4. Y. Gao, Y. Du*, W. Su*, Free amino group-directed C(sp2)–H arylation of α-amino-β-aryl esters by palladium catalysis, Chin. Chem. Lett., 2024, 35, 108505.
5. Y. Huang, Y. Du*, W. Su*, Convenient and flexible syntheses of gem-dimethyl carboxylic triggers via mono-selective β-C(sp3)–H arylation of pivalic acid with ortho-substituted aryl iodides, Org. Chem. Front., 2022, 9, 3293–3300.
6. Y. Du, Y. Huang, Y. Gao, H. Shen, W. Su*, M. Hong*, Chiral ligands for palladium-catalyzed asymmetric C–H activation. Sci. Sin. Chim., 2021, 51, 123–143.
7. S. Ming, S. Qurban, Y. Du*, W. Su*, Asymmetric synthesis of multi-substituted tetrahydrofurans via palladium/rhodium synergistic catalyzed [3+2] decarboxylative cycloaddition of vinylethylene carbonates, Chem. Eur. J., 2021, 27, 12742–12746.
8. Q. Wan, L. Chen, S. Li, Q. Kang, Y. Yuan*, Y. Du*, Enantioselective synthesis of multisubstituted spirocyclopentane oxindoles enabled by Pd/chiral Rh(III) complex synergistic catalysis, Org. Lett., 2020, 22, 9539–9544.
9. K. Zhang#, Y. Du#, Z. Si#, Y. Liu, M. E. Turvey, C. Raju, D. Keogh, K. Pethe*, M. B. Chan-Park*, Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters, Nat. Commun., 2019, 10, 4792.
10. H. Zhang, S. Li, Q. Kang*, Y. Du*, Chiral-at-metal rhodium(III) complex catalyzed enantioselective synthesis of C2-substituted benzofuran derivatives, Org. Chem. Front., 2019, 6, 3683–3687.
11. S. Li, Y. Du*, Q. Kang*, A chiral-at-metal asymmetric catalyzed vinylogous Michael addition of ortho-methyl aromatic nitro compounds for isoxazole derivative synthesis, Org. Chem. Front., 2019, 6, 2775–2779.
12. S. Qurban#, Y. Du#, J. Gong, S.-X. Lin, Q. Kang*, Enantioselective synthesis of tetrahydroisoquinoline derivatives via chiral-at-metal rhodium complex catalyzed [3+2] cycloaddition, Chem. Commun., 2019, 55, 249–252.
13. Y. Zhang#, Y. Du#, Z. Huang, J. Xu, X. Wu, Y. Wang, M. Wang, S. Yang, R. D. Webster*, Y. Robin Chi*, N-Heterocyclic carbene-catalyzed radical reactions for highly enantioselective β-hydroxylation of enals, J. Am. Chem. Soc., 2015, 137, 2416–2419.
14. Y. Du, Y. Wang, X. Li, Y. Shao, G. Li*, R. D. Webster*, Y. Robin Chi*, N-Heterocyclic carbene organocatalytic reductive β,β-coupling reactions of nitroalkenes via radical intermediates, Org. Lett., 2014, 16, 5678–5681.