search
>
人才队伍
<

研究员

首页 > 人才队伍 > 研究员

房新强

  • 职称：研究员
  • 学科：
  • 电子邮件：xqfang@fjirsm.ac.cn
  • 研究方向：

    不对称催化，基于羰基类分子的合成和催化转化，精细有机化学品开发，药物和天然产物合成

简介

房新强，理学博士，中国科学院福建物质结构研究所研究员、课题组长、博士生导师。研究领域为不对称催化相关的合成化学，尤其是多位点羰基分子参与的催化转化及其在天然产物和药物分子合成中的应用，并注重与材料化学和化学生物学的结合，至今已在J. Am. Chem. Soc.、 Angew. Chem. Int. Ed.、 Nat. Commun.、ACS Catal.等杂志上发表论文七十多篇，受邀撰写英文专著一章。 2013年9月以海西院“百人计划”引进到中国科学院福建物质结构研究所工作，任研究员，课题组长。2015年入选国家引进高层次人才青年项目，同年入选中国科学院高层次人才和福建省引进高层次创新人才计划，受邀担任中国《有机化学》杂志青年编委和Springer Nature 出版社Discover Chemistry编委，是Nat. Chem.、 J. Am. Chem. Soc.、Angew. Chen. Int. Ed.、Nat. Commun. 、 ACS Catal.等国际知名期刊审稿人，并多次参加基金委、科技部、中组部项目评审。

代表性论著

1. S. Lan#, Q. Cui#, D. Luo, S. Shi, C. He, S. Huang, C. Xu, L. Zhao, J. Liu*, C.-Z. Gu*, S. Yang, X. Fang*, Copper-Catalyzed Asymmetric Nucleophilic Opening of 1,1,2,2-Tetrasubstituted Donor-Acceptor Cyclopropanes for the Synthesis of α-Tertiary Amines, Journal of the American Chemical Society, 2025, 147(1), 1172-1185.

2. Z. Zhao#, W. Dong#, J. Liu, S. Yang, A. E. Cotman, Q. Zhang*, X. Fang*, Catalytic Asymmetric Transfer Hydrogenation of β,γ-Unsaturated α-Diketones, Journal of the American Chemical Society, 2024, 146(49), 33543-33560.

3. W. Liu, C. Ren, L. Zhou, H. Luo, X. Meng, P. Luo, Y. Luo, W. Dong, S. Lan, J. Liu, S. Yang, Q. Zhang*, X. Fang*, Regio- and Stereoselective Transfer Hydrogenation of Aryloxy Group-Substituted Unsymmetrical 1,2-Diketones: Synthetic Applications and Mechanistic Studies, Journal of the American Chemical Society, 2024, 146(29), 20092-20106.

4. X. Meng#, S. Lan#, T. Chen, H. Luo, L. Zhu, N. Chen, J. Liu, S. Yang, A. E. Cotman, Q. Zhang*, X. Fang*, Catalytic Asymmetric Transfer Hydrogenation of Acylboronates: BMIDA as the Privileged Directing Group, Journal of the American Chemical Society, 2024, 146(29), 20357-20369.

5. S. Lan#, H. Huang#, W. Liu, C. Xu, X. Lei, W. Dong, J. Liu, S. Yang, A. E. Cotman, Q. Zhang*, X. Fang*, Asymmetric Transfer Hydrogenation of Cyclobutenediones, Journal of the American Chemical Society, 2024, 146(7), 4942-4957.

6. D. Luo#, S. Niu#, F. Gong, C. Xu, S. Lan, J. Liu*, S. Yang, X. Fang*, Copper-catalyzed Asymmetric Yne-allylic Substitution Using Electron-rich Arenes, ACS Catalysis, 2024, 14(4), 2746-2757.

7. W. Dong, C. Ren, L. Zhu, P. Luo, Z. Zhao, S. Lan, J. Liu, S. Yang, Q. Zhang*, X. Fang*, Ruthenium-Catalyzed Formal Asymmetric Reductive Isomerization of α-Hydroxyenones, ACS Catalysis, 2024, 14(24), 18753-18764.

8. W. Dong, Z. Zhao, C. Gu*, J. Liu, S. Yang, X. Fang*, Copper-catalyzed Umpolung Reactivity of Propargylic Carbonates in the Presence of Diboronates: One Stone Four Birds, Journal of the American Chemical Society, 2023, 145(50), 27539-27554.

9. H. Zhang#, C. Xu#, S. Lan, J. Liu, S. Yang, Q. Zhang*, X. Fang*, Copper-Catalyzed Skeletal Rearrangement of Cyclic Ethynylethylene Carbonates: Synthetic Applications and Mechanistic Studies, Angewandte Chemie International Edition, 2023, 62(14), e202219064.

10. T. Chen#, W. Liu#, W. Gu, S. Niu, S. Lan, Z. Zhao, F. Gong, J. Liu, S. Yang, A. E. Cotman, J. Song*, X. Fang*, Dynamic Kinetic Resolution of β-Substituted α-Diketones via Asymmetric Transfer Hydrogenation, Journal of the American Chemical Society, 2023, 145(1), 585-599.

11. F. Gong#, X. Meng#, S. Lan, J. Liu, S. Yang, X. Fang*, Asymmetric Semipinacol Rearrangement Enabled by Copper-Catalyzed Propargylic Alkylation, ACS Catalysis, 2022, 12(19), 12036-12044.

12. S. Niu, Y. Luo, C. Xu, J. Liu, S. Yang, X. Fang*, Copper-Catalyzed Yne-Allylic Substitutions Using Stabilized Nucleophiles, ACS Catalysis, 2022, 12(12), 6840-6850.

13. S. Niu#, H. Zhang#, W. Xu*, P. R. Bagdi, G. Zhang, J. Liu, S. Yang, X. Fang*, Access to Enantioenriched Compounds Bearing Challenging Tetrasubstituted Stereocenters via Kinetic Resolution of Auxiliary Adjacent Alcohols, Nature Communications, 2021, 12(1), 3735.

14. J. Liu#, L. Vasamsetty#, M. Anwar#, S. Yang,* W. Xu, J. Liu, S. Nagaraju, X. Fang*, Organocatalyzed Kinetic Resolution of α-Functionalized Ketones: the Malonate Unit Leads the Way, ACS Catalysis, 2020, 10(5), 2882-2893.

15. G. Zhang, S. Yang, X. Zhang, Q. Lin, D. K. Das, J. Liu, X. Fang*, Dynamic Kinetic Resolution Enabled by Intramolecular Benzoin Reaction: Synthetic Applications and Mechanistic Insights, Journal of the American Chemical Society, 2016, 138(25), 7932-7938.